Courses@CRG: Tissue engineering course

Direcci贸nDr. Aiguader, 88
?Lugar?Centre for Genomic Regulation - CRG
ProvinciaBarcelona (B)
De fecha30/07/2018
A fecha03/08/2018
P谩gina ofici谩l
P谩gina Facebook

Dr. Aiguader, 88
Centre for Genomic Regulation - CRG
Barcelona (B)
Tel 2018-07-30
Categoria Eventos

Organoids are revolutionizing the fields of developmental and stem cell biology as they have enabled the in vitro generation of complex structures resembling whole organs. They can be generated either from resident progenitors in adult organs or from pluripotent stem cells (ES and iPSc). When stem cells are grown in a 3D environment, they recapitulate the mechanisms of organogenesis seen in vivo. They are able to differentiate, go through the processes of cell-sorting and acquire the specific tissue patterning to develop into several endoderm- mesodem and ectoderm-derived tissues, mimicking their in vivo counterparts. These complex structures provide a unique opportunity to model human organ development in a system remarkably similar to development in vivo. Selected participants will get an overview of the background and current methods for the generation and characterization of pluripotent stem cells, organoids and their genetic manipulation by CRISPR/Cas9 technology.

They will have the opportunity to learn and practice how to generate and characterize: 鈥ouse embryonic stem cells and induced pluripotent stem cells 鈥erebral, liver and intestinal organoids 鈥enetically modified organoids by CRISPR/Cas9 technology

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